catalog number :
MBS035971
products type :
ELISA Kit
products full name :
Bovine Glycogen Phosphorylase, Muscle ELISA Kit
products short name :
Glycogen Phosphorylase, Muscle
other names :
glycogen phosphorylase, muscle form isoform 1; Glycogen phosphorylase, muscle form; glycogen phosphorylase, muscle form; myophosphorylase; phosphorylase, glycogen, muscle; Myophosphorylase
products gene name :
PYGM
other gene names :
PYGM; PYGM
uniprot entry name :
PYGM_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Bovine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.625ng/ml-20ng/ml. Sensitivity: 0.1ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PYGM (hereafter termed "analyte") in undiluted original Bovine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_005600.1
ncbi gb acc num :
NM_005609.2
ncbi mol weight :
97,092 Da
ncbi pathways :
Disease Pathway (530764); Glucose Metabolism Pathway (106199); Glycogen Metabolism Pathway (198856); Glycogen Breakdown (glycogenolysis) Pathway (106212); Glycogen Storage Diseases Pathway (980468); Insulin Signaling Pathway (83090); Insulin Signaling Pathway (501); Metabolism Pathway (477135); Metabolism Of Carbohydrates Pathway (106196); Myoclonic Epilepsy Of Lafora Pathway (980469)
ncbi summary :
This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
uniprot summary :
PYGM: an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Dimers associate into a tetramer to form the enzymatically active phosphorylase A. Phosphorylation of Ser-14 converts phosphorylase B (unphosphorylated) to phosphorylase A. Protein type: Transferase; EC 2.4.1.1; Endoplasmic reticulum; Carbohydrate Metabolism - starch and sucrose; Phosphorylase. Chromosomal Location of Human Ortholog: 11q12-q13.2. Cellular Component: cytosol. Molecular Function: glycogen phosphorylase activity; nucleotide binding; pyridoxal phosphate binding. Biological Process: glycogen metabolic process; glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis. Disease: Glycogen Storage Disease V