Human Versican ELISA Kit | MyBioSource MBS035864 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Versican ELISA Kit

catalog :

MBS035864

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS035864

products type :

ELISA Kit

products full name :

Human Versican ELISA Kit

products short name :

Versican

other names :

versican core protein isoform 1; Versican core protein; versican core protein; versican proteoglycan; large fibroblast proteoglycan; glial hyaluronate-binding protein; chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan core protein 2; versican; Chondroitin sulfate proteoglycan core protein 2; Chondroitin sulfate proteoglycan 2; Glial hyaluronate-binding protein; GHAP; Large fibroblast proteoglycan; PG-M

products gene name :

VCAN

other gene names :

VCAN; VCAN; WGN; ERVR; GHAP; PG-M; WGN1; CSPG2; CSPG2; Chondroitin sulfate proteoglycan 2; GHAP

uniprot entry name :

CSPG2_HUMAN

reactivity :

Human

sequence length :

3396

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma, Tissue Homogenate and other Body Fluid. Assay Type: Sandwich. Detection Range: 6.25 ng/ml - 200 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of VCAN (hereafter termed this analyte) in undiluted original Human serum, plasma, tissue homogenate and body fluid samples.

ncbi gi num :

21361116

ncbi acc num :

NP_004376.2

ncbi gb acc num :

NM_004385.4

uniprot acc num :

P13611

ncbi mol weight :

372,820 Da

ncbi pathways :

A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway (645305); CS/DS Degradation Pathway (645311); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Chondroitin Sulfate Biosynthesis Pathway (645309); Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway (645308); Dermatan Sulfate Biosynthesis Pathway (645310); Direct P53 Effectors Pathway (137939); Disease Pathway (530764); ECM Proteoglycans Pathway (833812)

ncbi summary :

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

uniprot summary :

CSPG2: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1). WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN. Belongs to the aggrecan/versican proteoglycan family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Cell adhesion; Secreted. Chromosomal Location of Human Ortholog: 5q14.3. Cellular Component: extracellular matrix; lysosomal lumen; proteinaceous extracellular matrix; extracellular space; intracellular membrane-bound organelle; membrane; Golgi lumen; extracellular region. Molecular Function: protein binding; glycosaminoglycan binding; extracellular matrix structural constituent; hyaluronic acid binding; calcium ion binding; carbohydrate binding. Biological Process: extracellular matrix organization and biogenesis; central nervous system development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; heart development; multicellular organismal development; pathogenesis; cell recognition; glial cell migration; dermatan sulfate biosynthetic process; osteoblast differentiation; chondroitin sulfate metabolic process; chondroitin sulfate catabolic process; carbohydrate metabolic process; cell adhesion; skeletal development. Disease: Wagner Vitreoretinopathy

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage