ELISA/assay

Mouse Peroxisome Proliferators Activator gammaelisa ELISA Kit

MBS035522

96 Strip Wells

600 USD

ELISA Kit

Mouse Peroxisome Proliferators Activator gammaelisa ELISA Kit

Peroxisome Proliferators Activator gammaelisa

Peroxisome proliferator-activated receptor gamma; Peroxisome proliferator-activated receptor gamma; peroxisome proliferator-activated receptor gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated nuclear receptor gamma variant 1; peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3

PPAR-gamma

PPARG; PPARG; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; NR1C3; PPAR-gamma

PPARG_HUMAN

Mouse

505

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

13432234

P37231.3

P37231

57,620 Da

AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adipogenesis Pathway 198832!!Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway 137993!!Developmental Biology Pathway 477129!!Energy Metabolism Pathway 198907!!Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 160977!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Huntington's Disease Pathway 83100

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

Function: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Ref.1 Ref.23 Ref.25 Ref.27. Enzyme regulation: PDPK1 activates its transcriptional activity independently of its kinase activity. Ref.23. Subunit structure: Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with CCRN4L/NOC. Ref.16 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.26 Ref.27 Ref.29. Subcellular location: Nucleus. Cytoplasm. Note: Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation. Ref.24 Ref.27. Tissue specificity: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. Ref.1. Post-translational modification: O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes . By similarity.Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity . By similarity. Polymorphism: Genetic variation in PPARG may influence body mass index (BMI) [. MIM:606641]. BMI reflects the amount of fat, lean mass, and body build.Genetic variations in PPARG influence the carotid intimal medial thickness (CIMT) [. MIM:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors. Involvement in disease: Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Ref.42Lipodystrophy, familial partial, 3 (FPLD3) [MIM:604367]: A form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.48 Ref.49Glioma 1 (GLM1) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility. Sequence similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain. Sequence caution: The sequence AAN38992.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAA23354.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAF83270.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA62153.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

96 Strip Wells

600 USD