ELISA/assay

Goose A Disintegrin and Metalloprotease 19 ELISA Kit

MBS035072

96 Strip Wells

600 USD

ELISA Kit

Goose A Disintegrin and Metalloprotease 19 ELISA Kit

A Disintegrin and Metalloprotease 19

ADAM19 protein, partial; Disintegrin and metalloproteinase domain-containing protein 19; disintegrin and metalloproteinase domain-containing protein 19; ADAM 19; meltrin-beta; metalloprotease-disintegrin meltrin beta; metalloprotease and disintegrin dendritic antigen marker; a disintegrin and metalloproteinase domain 19 (meltrin beta); ADAM metallopeptidase domain 19; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker

ADAM19

ADAM19; ADAM19; MLTNB; FKSG34; MADDAM; MLTNB; ADAM 19; MADDAM

ADA19_HUMAN

Goose

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

38197238

AAH24214.2

Q9H013

104,997 Da

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone . By similarity. Cofactor: Binds 1 zinc ion per subunit . By similarity. Subunit structure: Interacts with SH3PXD2A. Ref.6. Subcellular location: Membrane; Single-pass type I membrane protein. Tissue specificity: Expressed in many normal organ tissues and several cancer cell lines. Induction: By 1,25(OH)2VD3 in monocytes. Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. Post-translational modification: The precursor is cleaved by a furin endopeptidase . By similarity. Sequence similarities: Contains 1 disintegrin domain.Contains 1 EGF-like domain.Contains 1 peptidase M12B domain.

96 Strip Wells

600 USD