ELISA/assay

Human Trypsinogen Activation Peptide ELISA Kit

MBS035018

96 Strip Wells

600 USD

ELISA Kit

Human Trypsinogen Activation Peptide ELISA Kit

Trypsinogen Activation Peptide

Trypsin-1; Trypsin-1; trypsin-1; beta-trypsin; trypsinogen 1; trypsinogen A; digestive zymogen; cationic trypsinogen; nonfunctional trypsin 1; protease, serine, 1 (trypsin 1); Beta-trypsin; Cationic trypsinogen; Serine protease 1; Trypsin I

TAP

PRSS1; PRSS1; TRP1; TRY1; TRY4; TRYP1; TRP1; TRY1; TRYP1

TRY1_HUMAN

Human

247

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

136408

P07477.1

P07477

26,558 Da

Activation Of Matrix Metalloproteinases Pathway 576264!!Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway 833804!!Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway 906000!!Defective BTD Causes Biotidinase Deficiency Pathway 906015!!Defective CD320 Causes Methylmalonic Aciduria Pathway 906012!!Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway 906001!!Defective GIF Causes Intrinsic Factor Deficiency Pathway 906004!!Defective HLCS Causes Multiple Carboxylase Deficiency Pathway 906014!!Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway 906003!!Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway 906010

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

Function: Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. Ref.9. Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa. Cofactor: Binds 1 calcium ion per subunit. Subcellular location: Secreted extracellular space. Post-translational modification: Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122. Involvement in disease: Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.8 Ref.11 Ref.12 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23. Sequence similarities: Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain. Caution: Tyr-154 was proposed to be phosphorylated (Ref.15) but it has been shown (Ref.14) to be sulfated instead. Phosphate and sulfate groups are similar in mass and size, and this can lead to erroneous interpretation of the results. Mass spectrometry: Molecular mass is 24348 2 Da from positions 24 - 247. Determined by ESI. Ref.15

96 Strip Wells

600 USD