catalog number :
MBS034175
products type :
ELISA Kit
products full name :
Mouse Bone Sialoprotein ELISA Kit
products short name :
Bone Sialoprotein
other names :
bone sialoprotein 2; Bone sialoprotein 2; bone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein; integrin-binding sialoprotein; Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein
other gene names :
IBSP; IBSP; BSP; BNSP; SP-II; BSP-II; BNSP; BSP II
uniprot entry name :
SIAL_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
ELISA Type: Sandwich
ncbi acc num :
NP_004958.2
ncbi gb acc num :
NM_004967.3
ncbi mol weight :
35,148 Da
ncbi pathways :
ECM Proteoglycans Pathway 833812!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Extracellular Matrix Organization Pathway 576262!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!Integrin Cell Surface Interactions Pathway 106110!!Interleukin-11 Signaling Pathway 698753!!Osteoblast Signaling Pathway 198842
ncbi summary :
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. Subcellular location: Secreted. Post-translational modification: N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains. Ref.6O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. Ref.6Sulfated on either Tyr-313 or Tyr-314. Miscellaneous: It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.