catalog number :
MBS033124
products type :
ELISA Kit
products full name :
Bovine Hormone Sensitive Lipase ELISA Kit
products short name :
Hormone Sensitive Lipase
other names :
hormone-sensitive lipase; Hormone-sensitive lipase; hormone-sensitive lipase; hormone-sensitive lipase testicular isoform; lipase, hormone-sensitive
other gene names :
LIPE; LIPE; HSL; LHS; HSL
uniprot entry name :
LIPS_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
ELISA Type: Sandwich
ncbi acc num :
NP_005348.2
ncbi gb acc num :
NM_005357.2
ncbi mol weight :
116,598 Da
ncbi pathways :
AMPK Signaling Pathway 198868!!Adipogenesis Pathway 198832!!Fatty Acid Beta Oxidation Pathway 198865!!Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway 106121!!Insulin Signaling Pathway 198845!!Insulin Signaling Pathway 83090!!Insulin Signaling Pathway 501!!Lipid Digestion, Mobilization, And Transport Pathway 106111!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976
ncbi summary :
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Catalytic activity: Diacylglycerol + H2O = monoacylglycerol + a carboxylate.Triacylglycerol + H2O = diacylglycerol + a carboxylate.Monoacylglycerol + H2O = glycerol + a carboxylate. Enzyme regulation: Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. Pathway: Glycerolipid metabolism; triacylglycerol degradation. Subunit structure: Interacts with PTRF in the adipocyte cytoplasm. Ref.5. Subcellular location: Cell membrane. Membrane caveola. Cytoplasm cytosol. Note: Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. Ref.5 Ref.6. Post-translational modification: Phosphorylation by AMPK may block translocation to lipid droplets . By similarity. Sequence similarities: Belongs to the 'GDXG' lipolytic enzyme family.