Mouse Pyruvate Kinase, Liver and Rbc ELISA Kit | MyBioSource MBS032422 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Pyruvate Kinase, Liver and Rbc ELISA Kit

catalog :

MBS032422

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS032422

products type :

ELISA Kit

products full name :

Mouse Pyruvate Kinase, Liver and Rbc ELISA Kit

products short name :

[Pyruvate Kinase, Liver and Rbc]

other names :

[pyruvate kinase PKLR isoform 2; Pyruvate kinase PKLR; pyruvate kinase PKLR; pyruvate kinase 1; pyruvate kinase type L; pyruvate kinase isozyme R/L; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; R-type/L-type pyruvate kinase; red cell/liver pyruvate kinase; pyruvate kinase, liver and blood cell; pyruvate kinase, liver and RBC; Pyruvate kinase 1; Pyruvate kinase isozymes L/R; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase]

products gene name :

[PKLR]

other gene names :

[PKLR; PKLR; PK1; PKL; PKR; RPK; PKRL; PK1; PKL]

uniprot entry name :

KPYR_HUMAN

reactivity :

Mouse

sequence length :

543

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PKLR (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

32967597

ncbi acc num :

NP_870986.1

ncbi gb acc num :

NM_181871.3

uniprot acc num :

P30613

ncbi mol weight :

61,830 Da

ncbi pathways :

Adenine Ribonucleotide Biosynthesis, IMP = ADP,ATP Pathway (618580); Adenine Ribonucleotide Biosynthesis, IMP = ADP,ATP Pathway (468242); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); ChREBP Activates Metabolic Gene Expression Pathway (106104); Developmental Biology Pathway (477129); Disease Pathway (530764); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911)

ncbi summary :

The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

PKLR: one of three rate-limiting enzymes in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule ATP and a pyruvate molecule, which is a central metabolic intermediate that can be used as a building block or oxidized further. There are several mammalian isozymes of pyruvate kinase encoded by different genes. The L type predominates in liver, and the M type in muscle and brain. Two alternatively spliced human isoforms have been described: the R- and L-types. Protein type: EC 2.7.1.40; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Nucleotide Metabolism - purine; Kinase, other; Carbohydrate Metabolism - pyruvate. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: cytosol. Molecular Function: potassium ion binding; magnesium ion binding; pyruvate kinase activity; ATP binding. Biological Process: pyruvate biosynthetic process; glycolysis; response to cAMP; response to lithium ion; positive regulation of cellular metabolic process; glucose metabolic process; pathogenesis; response to other organism; endocrine pancreas development; response to ATP; cellular response to insulin stimulus; response to heat; ATP biosynthetic process; carbohydrate metabolic process; response to hypoxia; energy reserve metabolic process; response to glucose stimulus; phosphorylation; response to nutrient. Disease: Adenosine Triphosphate, Elevated, Of Erythrocytes; Pyruvate Kinase Deficiency Of Red Cells

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095