Porcine Von Willebrand Factor ELISA Kit | MyBioSource MBS031845 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Porcine Von Willebrand Factor ELISA Kit

catalog :

MBS031845

quantity :

96 Strip Wells

price :

600 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS031845

products type :

ELISA Kit

products full name :

Porcine Von Willebrand Factor ELISA Kit

products short name :

Von Willebrand Factor

other names :

von Willebrand factor preproprotein; von Willebrand factor; von Willebrand factor; coagulation factor VIII VWF; von Willebrand factor; von Willebrand antigen II

products gene name :

VWF

other gene names :

VWF; VWF; VWD; F8VWF; F8VWF; vWF

uniprot entry name :

VWF_HUMAN

reactivity :

Porcine

storage stability :

Store all reagents at 2-8 degree C

other info1 :

ELISA Type: Sandwich

ncbi gi num :

89191868

ncbi acc num :

NP_000543.2

ncbi gb acc num :

NM_000552.3

uniprot acc num :

P04275

ncbi mol weight :

309,265 Da

ncbi pathways :

Blood Clotting Cascade Pathway 198840!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057

ncbi summary :

The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Subunit structure: Multimeric. Interacts with F8. Ref.19 Ref.22. Subcellular location: Secreted. Secreted extracellular space extracellular matrix. Note: Localized to storage granules. Ref.19. Tissue specificity: Plasma. Domain: The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. Post-translational modification: All cysteine residues are involved in intrachain or interchain disulfide bonds.N- and O-glycosylated. Ref.21. Involvement in disease: von Willebrand disease 1 (VWD1) [MIM:193400]: A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.59 Ref.60von Willebrand disease 2 (VWD2) [MIM:613554]: A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in altered platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet-dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35 Ref.36 Ref.37 Ref.38 Ref.39 Ref.40 Ref.41 Ref.42 Ref.43 Ref.44 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.53 Ref.54 Ref.55 Ref.56 Ref.57 Ref.58 Ref.61 Ref.64von Willebrand disease 3 (VWD3) [MIM:277480]: A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.51 Ref.52 Ref.59. Sequence similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 4 TIL (trypsin inhibitory-like) domains.Contains 3 VWFA domains.Contains 3 VWFC domains.Contains 4 VWFD domains. Sequence caution: The sequence AAB59512.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

size :

96 Strip Wells

price :

600 USD

more info or order :

MyBioSource product webpage