catalog number :
MBS031132
products type :
ELISA Kit
products full name :
Human Complement Fragment 5A ELISA Kit
products short name :
[Complement Fragment 5A]
other names :
[C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor 2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; C5a anaphylatoxin chemotactic receptor C5L2; complement component 5a receptor 2; Complement component 5a receptor 2; G-protein coupled receptor 77]
products gene name :
[C5A]
other gene names :
[C5AR2; C5AR2; C5L2; GPF77; GPR77; C5L2; GPR77]
uniprot entry name :
C5AR2_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 6.25 ng/ml - 200 ng/ml. Sensitivity: 1.0 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of C5A (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_060955.1
ncbi gb acc num :
NM_018485.2
ncbi mol weight :
36,080 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); GPCRs, Other Pathway (198765); Peptide Ligand-binding Receptors Pathway (106358); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)
ncbi summary :
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
uniprot summary :
C5AR2: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: apical part of cell; plasma membrane; integral to membrane; basal plasma membrane. Molecular Function: protein binding; C5a anaphylatoxin receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of tumor necrosis factor production; chemotaxis; inflammatory response; positive regulation of epithelial cell proliferation
size4 :
10x96-Strip-Wells