catalog number :
MBS030539
products type :
ELISA Kit
products full name :
Horse Neurotrophin-3 ELISA Kit
products short name :
[Neurotrophin-3]
other names :
[neurotrophin-3 isoform 1 preproprotein; Neurotrophin-3; neurotrophin-3; NT-3; neurotrophic factor; nerve growth factor 2; neurotrophin 3; HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor]
products gene name :
[NT-3]
other gene names :
[NTF3; NTF3; NT3; HDNF; NGF2; NGF-2; NT-3; NGF-2]
uniprot entry name :
NTF3_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Horse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 31.2pg/ml-1000pg/ml. Sensitivity: 5.0pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NT-3 (hereafter termed "analyte") in undiluted original Horse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001096124.1
ncbi gb acc num :
NM_001102654.1
ncbi mol weight :
29,355 Da
ncbi pathways :
BDNF Signaling Pathway (712093); Integrated Pancreatic Cancer Pathway (711360); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Neurotrophic Factor-mediated Trk Receptor Signaling Pathway (137977); Neurotrophin Signaling Pathway (101143); Neurotrophin Signaling Pathway (100064); Trk Receptor Signaling Mediated By The MAPK Pathway (138044); P75(NTR)-mediated Signaling Pathway (138019)
ncbi summary :
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
uniprot summary :
NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Cytokine; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region. Molecular Function: neurotrophin p75 receptor binding; growth factor activity; nerve growth factor binding; receptor binding; chemoattractant activity. Biological Process: myelination; axon guidance; mechanoreceptor differentiation; epidermis development; glial cell fate determination; regulation of neuron differentiation; activation of MAPK activity; positive regulation of receptor internalization; positive regulation of glial cell differentiation; signal transduction; enteric nervous system development; induction of positive chemotaxis; positive chemotaxis; cell-cell signaling; positive regulation of cell proliferation; negative regulation of neuron apoptosis; regulation of synaptic transmission; nervous system development; negative regulation of peptidyl-tyrosine phosphorylation; activation of protein kinase B; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; neuromuscular synaptic transmission; nerve development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; brain development; neurite morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
size4 :
10x96-Strip-Wells