Human B-Cell Activating Factor Receptor ELISA Kit | MyBioSource MBS030030 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human B-Cell Activating Factor Receptor ELISA Kit

catalog :

MBS030030

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS030030

products type :

ELISA Kit

products full name :

Human B-Cell Activating Factor Receptor ELISA Kit

products short name :

[B-Cell Activating Factor Receptor]

other names :

[BAFF receptor; Tumor necrosis factor receptor superfamily member 13C; tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; B cell-activating factor receptor; B-cell-activating factor receptor; tumor necrosis factor receptor superfamily, member 13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3]

products gene name :

[BAFFR]

other gene names :

[TNFRSF13C; TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; BAFFR; BR3; BAFF-R]

uniprot entry name :

TR13C_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of BAFFR (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

85567349

ncbi acc num :

AAI12031.1

uniprot acc num :

Q96RJ3

ncbi mol weight :

18,864 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); NF-kappa B Signaling Pathway (634527); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537)

ncbi summary :

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

uniprot summary :

BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Cell cycle regulation; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 22q13.1-q13.31. Cellular Component: integral to membrane; external side of plasma membrane. Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095