ELISA/assay

Goat Na+/Ca2+Exchanger ELISA Kit

MBS029401

48-Strip-Wells

470 USD

ELISA Kit

Goat Na+/Ca2+Exchanger ELISA Kit

[Na+/Ca2+Exchanger]

[Na+/Ca2+ exchanger; Sodium/calcium exchanger 1; sodium/calcium exchanger 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; Na(+)/Ca(2+)-exchange protein 1; solute carrier family 8 (sodium/calcium exchanger), member 1; Na(+)/Ca(2+)-exchange protein 1]

[NCX]

[SLC8A1; SLC8A1; NCX1; CNC; NCX1]

NAC1_HUMAN

Goat

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NCX (hereafter termed "analyte") in undiluted original Goat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

1008973

CAA62923.1

P32418

108,547 Da

Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285)

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

NCX1: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Motility/polarity/chemotaxis; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 2p22.1. Cellular Component: basolateral plasma membrane; integral to plasma membrane; T-tubule; plasma membrane; Z disc; sarcolemma. Molecular Function: calmodulin binding; metal ion binding; cytoskeletal protein binding; ankyrin binding; calcium:sodium antiporter activity. Biological Process: heart morphogenesis; embryonic placenta development; cellular sodium ion homeostasis; regulation of heart rate; vascular smooth muscle contraction; post-embryonic development; calcium ion homeostasis; cardiac muscle cell development; muscle contraction; reduction of cytosolic calcium ion concentration; embryonic heart tube development; ion transport; muscle fiber development; blood coagulation; transmembrane transport; regulation of the force of heart contraction; cardiac muscle contraction

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095