catalog number :
MBS028842
products type :
ELISA Kit
products full name :
Human Eosinophil Cationic Protein ELISA Kit
products short name :
Eosinophil Cationic Protein
other names :
eosinophil cationic protein; Eosinophil cationic protein; eosinophil cationic protein; RNase 3; ribonuclease 3; cytotoxic ribonuclease; ribonuclease, RNase A family, 3; Ribonuclease 3
other gene names :
RNASE3; RNASE3; ECP; RNS3; ECP; RNS3; ECP; RNase 3
uniprot entry name :
ECP_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 6.25 ng/ml - 200 ng/ml. Sensitivity: 1.0 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ECP (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.
ncbi acc num :
NP_002926.2
ncbi gb acc num :
NM_002935.2
ncbi mol weight :
18,385 Da
ncbi pathways :
Asthma Pathway (83120); Asthma Pathway (532)
ncbi summary :
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
uniprot summary :
RNASE3: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. Belongs to the pancreatic ribonuclease family. Protein type: Secreted; EC 3.1.27.-; Ribonuclease; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 14q11.2. Cellular Component: extracellular space; extracellular region. Molecular Function: nucleic acid binding; endonuclease activity; ribonuclease activity. Biological Process: defense response to Gram-positive bacterium; innate immune response in mucosa; RNA catabolic process; antibacterial humoral response