Mouse Angiostatin ELISA Kit | MyBioSource MBS027096 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Angiostatin ELISA Kit

catalog :

MBS027096

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS027096

products type :

ELISA Kit

products full name :

Mouse Angiostatin ELISA Kit

products short name :

Angiostatin

other names :

angiomotin isoform 2; Angiomotin; angiomotin; angiomotin p80 isoform; angiomotin p130 isoform; angiomotin

products gene name :

ANG

other gene names :

AMOT; AMOT; KIAA1071

uniprot entry name :

AMOT_HUMAN

reactivity :

Mouse

sequence length :

675

specificity :

No significant cross-reactivity or interference between Mouse ANG and analogues was observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intended Uses: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate ANG concentrations in Mouse serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications. Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]

products description :

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate ANG concentrations in Mouse serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications!

ncbi gi num :

19111150

ncbi acc num :

NP_573572.1

ncbi gb acc num :

NM_133265.2

uniprot acc num :

Q4VCS5

ncbi mol weight :

118,085 Da

ncbi pathways :

Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Signal Transduction Pathway (477114); Signaling By Hippo Pathway (576275)

ncbi summary :

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

AMOT: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Belongs to the angiomotin family. 2 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: Xq23. Cellular Component: signalosome; ruffle; tight junction; cell surface; lamellipodium; endocytic vesicle; cytoplasm; stress fiber; integral to membrane; actin filament; cytosol; external side of plasma membrane. Molecular Function: protein binding; angiostatin binding; receptor activity. Biological Process: intercellular junction assembly; blood vessel endothelial cell migration; positive regulation of cell size; in utero embryonic development; positive regulation of blood vessel endothelial cell migration; gastrulation with mouth forming second; chemotaxis; regulation of cell migration; negative regulation of angiogenesis; regulation of small GTPase mediated signal transduction; positive regulation of embryonic development; positive regulation of stress fiber formation; negative regulation of vascular permeability; actin cytoskeleton organization and biogenesis; vasculogenesis; cell migration involved in gastrulation

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage