Bovine Agrin ELISA Kit | MyBioSource MBS025586 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Bovine Agrin ELISA Kit

catalog :

MBS025586

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS025586

products type :

ELISA Kit

products full name :

Bovine Agrin ELISA Kit

products short name :

Agrin

other names :

agrin; Agrin; agrin; agrin proteoglycan; agrin

products gene name :

AGRIN

other gene names :

AGRN; AGRN; AGRIN; C90; C22

uniprot entry name :

AGRIN_HUMAN

reactivity :

Bovine

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma, Cell Culture Supernatants, Tissue Homogenate, Urine and other Body Fluids. Detection Range: 3.12 ng/ml ~ 100 ng/ml. Sensitivity: Typically less than 1.0 ng/ml.

other info2 :

Intended Uses: This ELISA kit is intended for laboratory in vitro research use only, not for drug, household or other use! The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm by a spectrophotometer. In order to measure the concentration of Bovine AGRIN in the specimen, this ELISA kit includes a set of calibration standards. The calibration standards are assayed at the same time as the specimens and allow the operator to produce a standard curve of Optical Density versus Bovine AGRIN concentration. The concentration of Bovine AGRIN in the specimens is then determined by comparing the O.D. of the specimens to the standard curve.

ncbi gi num :

2988422

ncbi acc num :

AAC39776.1

uniprot acc num :

O00468

ncbi mol weight :

217,232 Da

ncbi pathways :

A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway (645305); Axon Guidance Pathway (105688); Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway (645308); Developmental Biology Pathway (477129); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); ECM Proteoglycans Pathway (833812); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262)

ncbi summary :

This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. [provided by RefSeq, Aug 2011]

uniprot summary :

AGRN: Plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Ligand of the MUSK signaling complex that directly binds LRP4 in this complex and induces the phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Defects in AGRN are a cause of myasthenia, limb-girdle, familial (LGM). A congenital myasthenic syndrome characterized by a typical limb girdle pattern of muscle weakness with small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function. Protein type: Secreted; Cell development/differentiation; Cell adhesion; Extracellular matrix; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.33. Cellular Component: extracellular matrix; lysosomal lumen; extracellular space; cell surface; Golgi lumen; cytoplasm; extracellular region; plasma membrane; integral to membrane; basal lamina; synapse; cell junction. Molecular Function: heparan sulfate proteoglycan binding; protein binding; structural constituent of cytoskeleton; acetylcholine receptor regulator activity; laminin binding; calcium ion binding; sialic acid binding. Biological Process: positive regulation of filopodium formation; clustering of voltage-gated sodium channels; phototransduction, visible light; axon guidance; extracellular matrix organization and biogenesis; acetylcholine receptor signaling, muscarinic pathway; glycosaminoglycan metabolic process; neurotransmitter receptor metabolic process; pathogenesis; positive regulation of synaptic growth at neuromuscular junction; signal transduction; receptor clustering; chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; plasma membrane organization and biogenesis; positive regulation of neuron apoptosis; carbohydrate metabolic process; synapse organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of receptor activity; retinoid metabolic process; neuromuscular junction development. Disease: Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage