catalog number :
MBS025308
products type :
ELISA Kit
products full name :
Human Teratocarcinoma Derived Growth Factor 1 ELISA Kit
products short name :
[Teratocarcinoma Derived Growth Factor 1]
other names :
[teratocarcinoma-derived growth factor 1 isoform 2; Teratocarcinoma-derived growth factor 1; teratocarcinoma-derived growth factor 1; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1; teratocarcinoma-derived growth factor 1; Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1]
products gene name :
[TDGF1]
other gene names :
[TDGF1; TDGF1; CR; CRGF; CRIPTO; CRIPTO; CRGF]
uniprot entry name :
TDGF1_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TDGF1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001167607.1
ncbi gb acc num :
NM_001174136.1
ncbi mol weight :
21,169 Da
ncbi pathways :
Developmental Biology Pathway (477129); Glypican 1 Network Pathway (138010); Regulation Of Signaling By NODAL Pathway (477131); Signaling By NODAL Pathway (477130)
ncbi summary :
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
uniprot summary :
TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. Protein type: Membrane protein, peripheral; Cell adhesion; Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Cell cycle regulation. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: extrinsic to plasma membrane; Golgi apparatus; extracellular space; cell surface; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; nucleus; lipid raft. Molecular Function: protein binding; growth factor activity; receptor binding. Biological Process: somatic stem cell maintenance; activation of MAPK activity; heart development; regulation of signal transduction; gastrulation; Wnt receptor signaling pathway through beta-catenin; cardiac muscle cell differentiation; BMP signaling pathway; positive regulation of fibroblast proliferation; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; cell differentiation; vasculogenesis; epidermal growth factor receptor signaling pathway; in utero embryonic development; morphogenesis of a branching structure; embryonic development; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; negative regulation of apoptosis
size4 :
10x96-Strip-Wells