Monkey Cofilin 2, Muscle ELISA Kit | MyBioSource MBS024411 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Monkey Cofilin 2, Muscle ELISA Kit

catalog :

MBS024411

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS024411

products type :

ELISA Kit

products full name :

Monkey Cofilin 2, Muscle ELISA Kit

products short name :

Cofilin 2, Muscle

other names :

cofilin-2 isoform 2; Cofilin-2; cofilin-2; cofilin, muscle isoform; nemaline myopathy type 7; cofilin 2 (muscle); Cofilin, muscle isoform

products gene name :

CFL2

other gene names :

CFL2; CFL2; NEM7

uniprot entry name :

COF2_HUMAN

reactivity :

Monkey

specificity :

No significant cross-reactivity or interference between Monkey CFL2 and analogues was observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Assay Type: Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml.

other info2 :

Intended Uses: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This Quantitative Sandwich ELISA kit is in tended to determinate CFL2 concentrations in Monkey serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications. Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]

products description :

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This Quantitative Sandwich ELISA kit is in tended to determinate CFL2 concentrations in Monkey serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications!

ncbi gi num :

343887344

ncbi acc num :

NP_001230574.1

ncbi gb acc num :

NM_001243645.1

uniprot acc num :

Q9Y281

ncbi mol weight :

18,737 Da

ncbi pathways :

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Caspase Cascade In Apoptosis Pathway (137974); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); G13 Signaling Pathway (198800); Leptin Signaling Pathway (672456); Pertussis Pathway (218111); Pertussis Pathway (218099); Regulation Of Actin Cytoskeleton Pathway (198874)

ncbi summary :

This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

uniprot summary :

Cofilin-2: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 14q12. Cellular Component: I band; extracellular space; nuclear matrix; actin cytoskeleton. Molecular Function: protein binding; actin binding. Biological Process: muscle maintenance; actin filament depolymerization; positive regulation of actin filament depolymerization; sarcomere organization. Disease: Nemaline Myopathy 7

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage