Human Corticotropin Releasing Hormone ELISA Kit | MyBioSource MBS023886 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Corticotropin Releasing Hormone ELISA Kit

catalog :

MBS023886

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS023886

products type :

ELISA Kit

products full name :

Human Corticotropin Releasing Hormone ELISA Kit

products short name :

Corticotropin Releasing Hormone

other names :

corticotropin releasing hormone; Corticoliberin; corticoliberin; corticotropin-releasing factor; corticotropin releasing hormone; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone

products gene name :

CRH

other gene names :

CRH; CRH; CRF; CRF

uniprot entry name :

CRF_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Quantitative Sandwich. Detection Range: 0.625 pg/ml - 20 pg/ml. Sensitivity: 0.1 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of CRH (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

119607303

ncbi acc num :

EAW86897.1

uniprot acc num :

P06850

ncbi mol weight :

21,422 Da

ncbi pathways :

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Class B/2 (Secretin Family Receptors) Pathway (106378); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Long-term Depression Pathway (83086); Long-term Depression Pathway (497); Myometrial Relaxation And Contraction Pathways (198759); Rapid Glucocorticoid Signaling Pathway (137923)

ncbi summary :

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]

uniprot summary :

CRH: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8q13. Cellular Component: extracellular space; cytoplasm; extracellular region; perikaryon. Molecular Function: corticotropin-releasing hormone receptor 1 binding; neuropeptide hormone activity; protein binding; hormone activity; corticotropin-releasing hormone receptor 2 binding; receptor binding; adrenocorticotropin-releasing hormone activity. Biological Process: synaptic transmission, dopaminergic; negative regulation of circadian sleep/wake cycle, REM sleep; diterpenoid metabolic process; positive regulation of cortisol secretion; hypothalamus development; induction of apoptosis by hormones; response to pain; female pregnancy; signal transduction; positive regulation of adrenocorticotropic hormone secretion; negative regulation of luteinizing hormone secretion; synaptic transmission; learning and/or memory; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; feeding behavior; parturition; negative regulation of blood pressure; response to electrical stimulus; inflammatory response; associative learning; response to corticosterone stimulus; response to drug; adrenal gland development; response to ether; response to ethanol; long-term memory; ion homeostasis; response to estrogen stimulus; regulation of serotonin secretion; negative regulation of epinephrine secretion; positive regulation of protein amino acid phosphorylation; glucocorticoid biosynthetic process; lung development. Disease: Acth Deficiency, Isolated

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage