Fish Nicotinic Acetylcholine Receptor ELISA Kit | MyBioSource MBS023715 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Fish Nicotinic Acetylcholine Receptor ELISA Kit

catalog :

MBS023715

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS023715

products type :

ELISA Kit

products full name :

Fish Nicotinic Acetylcholine Receptor ELISA Kit

products short name :

Nicotinic Acetylcholine Receptor

other names :

nicotinic acetylcholine receptor; Neuronal acetylcholine receptor subunit alpha-4; neuronal acetylcholine receptor subunit alpha-4; cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal nicotinic acetylcholine receptor alpha-4 subunit; cholinergic receptor, nicotinic, alpha 4 (neuronal)

products gene name :

N-ACHR

other gene names :

CHRNA4; CHRNA4; EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4; NACRA4

uniprot entry name :

ACHA4_HUMAN

reactivity :

Fish

specificity :

No significant cross-reactivity or interference between Fish N-ACHR and analogues was observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Assay Type: Sandwich. Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]

products description :

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate N-ACHR concentrations in Fish serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications!

ncbi gi num :

854159

ncbi acc num :

CAA60959.1

uniprot acc num :

P43681

ncbi mol weight :

69,957 Da

ncbi pathways :

Acetylcholine Binding And Downstream Events Pathway (106535); Activation Of Nicotinic Acetylcholine Receptors Pathway (161027); Cholinergic Synapse Pathway (217716); Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway (161029); Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway (161032); Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway (161030); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Neuronal System Pathway (106513); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (106534)

ncbi summary :

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

uniprot summary :

nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Protein type: Receptor, misc.; Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 20q13.33. Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; membrane; cell soma; dendrite; plasma membrane; integral to membrane; cell junction; external side of plasma membrane. Molecular Function: acetylcholine receptor activity; acetylcholine binding; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity. Biological Process: response to nicotine; regulation of action potential; B cell activation; behavioral response to nicotine; locomotory behavior; respiratory gaseous exchange; signal transduction; DNA repair; sensory perception of pain; regulation of dopamine secretion; synaptic transmission, cholinergic; neurological system process; synaptic transmission; membrane depolarization; regulation of inhibitory postsynaptic membrane potential; regulation of membrane potential; calcium ion transport; response to hypoxia; ion transport; response to oxidative stress; cognition. Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage