ELISA/assay

Rat Urokinase-Type Plasminogen Activator Receptor ELISA Kit

MBS023381

96 Strip Wells

600 USD

ELISA Kit

Rat Urokinase-Type Plasminogen Activator Receptor ELISA Kit

Urokinase-Type Plasminogen Activator Receptor

urokinase plasminogen activator surface receptor isoform 1; Urokinase plasminogen activator surface receptor; urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; urokinase-type plasminogen activator (uPA) receptor; plasminogen activator, urokinase receptor; Monocyte activation antigen Mo3

U-PAR

PLAUR; PLAUR; CD87; UPAR; URKR; U-PAR; MO3; UPAR; U-PAR; uPAR

UPAR_HUMAN

Rat

335

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

4505865

NP_002650.1

NM_002659.3

Q03405

36,978 Da

Arf6 Downstream Pathway 138038!!Attachment Of GPI Anchor To UPAR Pathway 106239!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Dissolution Of Fibrin Clot Pathway 106061!!FGF Signaling Pathway 137989!!Hemostasis Pathway 106028!!Metabolism Of Proteins Pathway 106230!!Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway 106236

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Subunit structure: Monomer . Probable. Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with SORL1. Ref.19 Ref.21 Ref.23. Subcellular location: Isoform 1: Cell membrane; Lipid-anchor GPI-anchor. Isoform 2: Secreted . Probable. Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. Sequence similarities: Contains 3 UPAR/Ly6 domains.

96 Strip Wells

600 USD