catalog number :
MBS023127
products type :
ELISA Kit
products full name :
Porcine Heparin ELISA Kit
products short name :
Heparin
other names :
heparin cofactor 2; Heparin cofactor 2; heparin cofactor 2; serpin D1; leuserpin 2; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1; serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1
products gene name :
HEPARIN
other gene names :
SERPIND1; SERPIND1; HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673; HCF2; HC-II; HLS2
uniprot entry name :
HEP2_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Porcine body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 62.5 U/L - 2000 U/L. Sensitivity: 10 U/L.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of HEP (hereafter termed "analyte") in undiluted original Porcine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_000176.2
ncbi gb acc num :
NM_000185.3
ncbi mol weight :
57,071 Da
ncbi pathways :
Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484)
ncbi summary :
The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2008]
uniprot summary :
SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family. Chromosomal Location of Human Ortholog: 22q11.21. Cellular Component: extracellular space; extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; heparin binding; endopeptidase inhibitor activity. Biological Process: chemotaxis; blood coagulation. Disease: Heparin Cofactor Ii Deficiency