catalog number :
MBS022625
products type :
ELISA Kit
products full name :
Rabbit Soluble Fms-Like Tyrosine Kinase Receptor 1 ELISA Kit
products short name :
Soluble Fms-Like Tyrosine Kinase Receptor 1
other names :
sFlt-1; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor 1; embryonic receptor kinase 2; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; vascular endothelial growth factor receptor-1; FMS-like tyrosine kinase 1; Embryonic receptor kinase 2; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase receptor FLT
products gene name :
SFLT-1
other gene names :
Flt1; Flt1; Flt-1; sFlt1; VEGFR1; VEGFR-1; AI323757; Emrk2; Flt; Vegfr1; VEGFR-1; FLT-1
uniprot entry name :
VGFR1_MOUSE
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma, Tissue Homogenate, Urine and other Body Fluids. Detection Range: 50 pg/ml ~ 1600 pg/ml.
other info2 :
Intended Uses: This ELISA kit is intended for laboratory in vitro research use only, not for drug, household or other use! The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm by a spectrophotometer. In order to measure the concentration of Rabbit SFLT-1 in the sample, this ELISA kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versus Rabbit SFLT-1 concentration. The concentration of Rabbit SFLT-1 in the samples is then determined by comparing the O.D. of the samples to the standard curve. Intended Uses: This ELISA kit is intended for laboratory in vitro research use only, not for drug, household or other use! The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm by a spectrophotometer. In order to measure the concentration of Rabbit SFLT-1 in the sample, this ELISA kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versus Rabbit SFLT-1 concentration. The concentration of Rabbit SFLT-1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
products description :
Background: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample.
ncbi acc num :
BAA24499.1
ncbi mol weight :
149,876 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Endocytosis Pathway (102286); Endocytosis Pathway (102181); Focal Adhesion Pathway (198353); Focal Adhesion Pathway (83264); Focal Adhesion Pathway (478); HIF-1 Signaling Pathway (695223); Id Signaling Pathway (198411); Neurophilin Interactions With VEGF And VEGFR Pathway (819803)
uniprot summary :
VEGFR1: a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis. Protein type: Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; Membrane protein, integral; TK group; VEGFR family. Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; integral to membrane; endosome; receptor complex. Molecular Function: transferase activity; identical protein binding; vascular endothelial growth factor receptor activity; protein-tyrosine kinase activity; growth factor binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity. Biological Process: cell migration; peptidyl-tyrosine phosphorylation; multicellular organismal development; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; chemotaxis; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; patterning of blood vessels; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of MAP kinase activity; monocyte chemotaxis; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; response to hypoxia; blood vessel morphogenesis; sprouting angiogenesis; embryonic morphogenesis; angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration