catalog number :
MBS022614
products type :
ELISA Kit
products full name :
Rat Keratan Sulfate ELISA Kit
products short name :
[Keratan Sulfate]
other names :
[keratan sulfate Gal-6-sulfotransferase; Carbohydrate sulfotransferase 1; carbohydrate sulfotransferase 1; carbohydrate (chondroitin 6/keratan) sulfotransferase 1; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; carbohydrate (keratan sulfate Gal-6) sulfotransferase 1; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; GST-1; Keratan sulfate Gal-6 sulfotransferase]
products gene name :
[KS]
other gene names :
[CHST1; CHST1; C6ST; KSST; GST-1; KS6ST; KSGal6ST; GST-1; KS6ST; KSGal6ST; KSST]
uniprot entry name :
CHST1_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 31.2 ng/ml - 1000 ng/ml. Sensitivity: 5.0 ng/ml.
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of KS (hereafter termed this analyte) in undiluted original Rat serum, plasma and tissue homogenate samples.
ncbi acc num :
BAA24840.1
ncbi mol weight :
46,715 Da
ncbi pathways :
Disease Pathway (530764); Glycogen Storage Diseases Pathway (980468); Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway (82983); Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway (357); Glycosaminoglycan Metabolism Pathway (645297); Keratan Sulfate Biosynthesis Pathway (645302); Keratan Sulfate/keratin Metabolism Pathway (645301); MPS I - Hurler Syndrome Pathway (685537); MPS II - Hunter Syndrome Pathway (685538); MPS IIIA - Sanfilippo Syndrome A Pathway (685539)
ncbi summary :
This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]
uniprot summary :
CHST1: Sulfotransferase that utilizes 3 -phospho-5 -adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. Protein type: Membrane protein, integral; EC 2.8.2.21; Transferase; Glycan Metabolism - keratan sulfate biosynthesis. Chromosomal Location of Human Ortholog: 11p11.2. Cellular Component: Golgi membrane; integral to membrane. Molecular Function: sulfotransferase activity; keratan sulfotransferase activity. Biological Process: keratan sulfate metabolic process; sulfur metabolic process; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; carbohydrate metabolic process; galactose metabolic process; pathogenesis; polysaccharide metabolic process; inflammatory response
size4 :
10x96-Strip-Wells