product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Dickkopf Related Protein 2 ELISA Kit
catalog :
MBS021448
quantity :
48-Strip-Wells
price :
435 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS021448
products type :
ELISA Kit
products full name :
Human Dickkopf Related Protein 2 ELISA Kit
products short name :
Dickkopf Related Protein 2
other names :
dickkopf-related protein 2; Dickkopf-related protein 2; dickkopf-related protein 2; hDkk-2; dickkopf-2; dickkopf 2 homolog; dickkopf homolog 2; dickkopf related protein-2; dickkopf WNT signaling pathway inhibitor 2
products gene name :
DKK2
other gene names :
DKK2; DKK2; DKK-2; Dickkopf-2; Dkk-2; hDkk-2
uniprot entry name :
DKK2_HUMAN
reactivity :
Human
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma and Tissue Homogenate. Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml. Assay Type: Sandwich
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DKK2 (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.
ncbi gi num :
7657023
ncbi acc num :
NP_055236.1
ncbi gb acc num :
NM_014421.2
uniprot acc num :
Q9UBU2
ncbi mol weight :
28,447 Da
ncbi pathways :
Presenilin Action In Notch And Wnt Signaling Pathway (137914); Wnt Signaling Pathway (83061); Wnt Signaling Pathway (471)
ncbi summary :
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
uniprot summary :
DKK2: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family. Protein type: Secreted; Secreted, signal peptide; Inhibitor. Chromosomal Location of Human Ortholog: 4q25. Cellular Component: extracellular space. Biological Process: Wnt receptor signaling pathway; multicellular organismal development
size1 :
48-Strip-Wells
price1 :
435 USD
size2 :
96-Strip-Wells
price2 :
600
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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