ELISA/assay

Human B7-H3 Gene ELISA Kit

MBS021298

48-Strip-Wells

435 USD

ELISA Kit

Human B7-H3 Gene ELISA Kit

B7-H3 Gene

B7-H3 protein; CD276 antigen; CD276 antigen; B7 homolog 3; costimulatory molecule; CD276 molecule; 4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule

B7-H3

CD276; CD276; B7H3; B7-H3; B7RP-2; 4Ig-B7-H3; B7H3; B7-H3

CD276_HUMAN

Human

Store all reagents at 2-8 degree C

Assay Type: Sandwich

52694705

CAE47548.1

Q5ZPR3

57,235 Da

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480)

The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

CD276: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 15q23-q24. Cellular Component: integral to membrane; external side of plasma membrane. Molecular Function: protein binding; receptor binding. Biological Process: cell proliferation; positive regulation of osteoblast differentiation; regulation of immune response; negative regulation of T cell proliferation; T cell activation; negative regulation of inflammatory response; negative regulation of interleukin-2 biosynthetic process; positive regulation of T cell proliferation; immune response; positive regulation of bone mineralization; positive regulation of interferon-gamma biosynthetic process; negative regulation of interferon-gamma biosynthetic process

48-Strip-Wells

435 USD

96-Strip-Wells

600