ELISA/assay

Human Apolipoprotein L1 ELISA Kit

MBS021236

48-Strip-Wells

435 USD

ELISA Kit

Human Apolipoprotein L1 ELISA Kit

Apolipoprotein L1

apolipoprotein L1 isoform c; Apolipoprotein L1; apolipoprotein L1; apolipoprotein L, 1; Apolipoprotein L; Apo-L; ApoL; Apolipoprotein L-I

APOL1

APOL1; APOL1; APOL; APO-L; FSGS4; APOL-I; APOL; Apo-L; ApoL; ApoL-I

APOL1_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.25 umol/L - 8 umol/L. Sensitivity: 0.1 umol/L.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of APOL1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

211938442

NP_001130013.1

NM_001136541.1

O14791

43,974 Da

African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Scavenging Of Heme From Plasma Pathway (771600)

This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

APOL1: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 (FSGS4). It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Belongs to the apolipoprotein L family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Lipid-binding; Channel, chloride; Secreted. Chromosomal Location of Human Ortholog: 22q13.1. Cellular Component: extracellular space; extracellular region; intrinsic to membrane. Molecular Function: protein binding; chloride channel activity; lipid binding. Biological Process: cholesterol metabolic process; receptor-mediated endocytosis; killing of cells of another organism; cytolysis; innate immune response; lipoprotein metabolic process; chloride transport; lipid transport. Disease: Focal Segmental Glomerulosclerosis 4, Susceptibility To

48-Strip-Wells

435 USD

96-Strip-Wells

600