catalog number :
MBS021185
products type :
ELISA Kit
products full name :
Sheep Insulin-Like Growth Factor-2 ELISA Kit
products short name :
Insulin-Like Growth Factor-2
other names :
insulin-like growth factor II isoform 1 preproprotein; Insulin-like growth factor II; insulin-like growth factor II; multiplication-stimulating polypeptide; insulin-like growth factor 2; IGF-II; Multiplication-stimulating polypeptide
products gene name :
IGF-2
other gene names :
Igf2; Igf2; Mpr; M6pr; Peg2; Igf-2; Igf-II; AL033362; Igf-2
uniprot entry name :
IGF2_MOUSE
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of IGF2 (hereafter termed this analyte) in undiluted original Sheep serum, plasma and tissue homogenate samples.
ncbi acc num :
NP_034644.2
ncbi gb acc num :
NM_010514.3
ncbi mol weight :
20,030 Da
ncbi pathways :
Apoptosis Pathway (198339); Endochondral Ossification Pathway (198336); Hedgehog Signaling Pathway (198414); Hemostasis Pathway (819701); IGF1R Signaling Cascade Pathway (819897); IRS-related Events Triggered By IGF1R Pathway (819899); Metabolism Of Proteins Pathway (819058); PI3K/Akt/mTOR Signaling Pathway (522982); Platelet Activation, Signaling And Aggregation Pathway (819711); Platelet Degranulation Pathway (819728)
uniprot summary :
Function: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Ref.7 Ref.8Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. Ref.7 Ref.8. Subcellular location: Secreted. Developmental stage: Low levels of expression during myoblast proliferation. Levels rise rapidly during myoblast differentiation and then decrease. Sequence similarities: Belongs to the insulin family.