Rabbit Activated Protein C ELISA Kit | MyBioSource MBS021088 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rabbit Activated Protein C ELISA Kit

catalog :

MBS021088

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS021088

products type :

ELISA Kit

products full name :

Rabbit Activated Protein C ELISA Kit

products short name :

[Activated Protein C]

other names :

[adenomatous polyposis coli protein isoform b; Adenomatous polyposis coli protein; adenomatous polyposis coli protein; deleted in polyposis 2.5; adenomatosis polyposis coli tumor suppressor; protein phosphatase 1, regulatory subunit 46; adenomatous polyposis coli; Deleted in polyposis 2.5]

products gene name :

[APC]

other gene names :

[APC; APC; GS; DP2; DP3; BTPS2; DP2.5; PPP1R46; DP2.5; Protein APC]

uniprot entry name :

APC_HUMAN

reactivity :

Rabbit

sequence length :

2843

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Mouse Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 0.25ng/ml-8ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of APC (hereafter termed "analyte") in undiluted original Mouse body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

53759122

ncbi acc num :

NP_000029.2

ncbi gb acc num :

NM_000038.5

uniprot acc num :

P25054

ncbi mol weight :

311,646 Da

ncbi pathways :

AMER1 Mutants Destabilize The Destruction Complex Pathway (1016198); APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway (1016193); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1016194); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1016197); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1016195); Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); BDNF Signaling Pathway (712093); Basal Cell Carcinoma Pathway (83113)

ncbi summary :

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

uniprot summary :

APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described. Protein type: Tumor suppressor; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 5q21-q22. Cellular Component: centrosome; tight junction; cytosol; beta-catenin destruction complex; nucleoplasm; kinetochore; cell-cell adherens junction; cytoplasmic microtubule; lamellipodium; cytoplasm; plasma membrane; nucleus; lateral plasma membrane. Molecular Function: microtubule plus-end binding; protein binding; cadherin binding; microtubule binding; gamma-catenin binding; beta-catenin binding; protein kinase regulator activity; protein kinase binding. Biological Process: positive regulation of cell adhesion; somatic stem cell maintenance; apoptosis; positive regulation of apoptosis; positive regulation of microtubule polymerization; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; cytoplasmic microtubule organization and biogenesis; muscle maintenance; anterior/posterior pattern formation; negative regulation of cell proliferation; regulation of osteoclast differentiation; hair follicle development; cytokinesis after mitosis; mitotic cell cycle spindle assembly checkpoint; positive regulation of epithelial cell differentiation; protein complex assembly; cell cycle arrest; cell adhesion; kidney development; proximal/distal pattern formation; cell structure disassembly during apoptosis; regulation of microtubule-based process; cell migration; regulation of attachment of spindle microtubules to kinetochore; negative regulation of odontogenesis; regulation of osteoblast differentiation; thymus development; negative regulation of microtubule depolymerization; negative regulation of MAPKKK cascade; axis specification; negative regulation of cyclin-dependent protein kinase activity; positive regulation of pseudopodium formation; axonogenesis; dorsal/ventral pattern formation; retina development in camera-type eye; positive regulation of cell division; positive regulation of protein catabolic process; regulation of nitrogen compound metabolic process; response to DNA damage stimulus; mitotic metaphase/anaphase transition; positive regulation of cell migration. Disease: Familial Adenomatous Polyposis 1; Gastric Cancer; Desmoid Disease, Hereditary; Colorectal Cancer; Hepatocellular Carcinoma

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage