ELISA/assay

Rat Bone Morphogenetic Protein 1 ELISA Kit

MBS021022

96 Strip Wells

600 USD

ELISA Kit

Rat Bone Morphogenetic Protein 1 ELISA Kit

Bone Morphogenetic Protein 1

bone morphogenetic protein 1 isoform 3; Bone morphogenetic protein 1; bone morphogenetic protein 1; procollagen C-proteinase; mammalian tolloid protein; procollagen C-endopeptidase; bone morphogenetic protein 1; Mammalian tolloid protein; mTld; Procollagen C-proteinase

BMP1

BMP1; BMP1; PCP; TLD; OI13; PCP2; PCOLC; PCOLC; BMP-1; mTld; PCP

BMP1_HUMAN

Rat

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

5453579

NP_006120.1

NM_006129.4

P13497

111,249 Da

Adipogenesis Pathway 198832!!Anchoring Fibril Formation Pathway 730307!!Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway 730306!!Cardiac Progenitor Differentiation Pathway 712094!!Collagen Biosynthesis And Modifying Enzymes Pathway 645289!!Collagen Formation Pathway 645288!!Crosslinking Of Collagen Fibrils Pathway 730308!!Extracellular Matrix Organization Pathway 576262!!HDL-mediated Lipid Transport Pathway 106158!!Lipid Digestion, Mobilization, And Transport Pathway 106111

This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]

Function: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX. Catalytic activity: Cleavage of the C-terminal propeptide at Ala- -Asp in type I and II procollagens and at Arg- -Asp in type III. Cofactor: Binds 1 zinc ion per subunit. Ref.11. Enzyme regulation: Activity is increased by the procollagen C-endopeptidase enhancer protein. Subunit structure: Interacts with POSTN, the interaction promotes deposition on the extracellular matrix . By similarity. Subcellular location: Golgi apparatus trans-Golgi network. Secreted extracellular space extracellular matrix. Note: Co-localizes with POSTN in the Golgi . By similarity. Ref.9. Tissue specificity: Ubiquitous. Post-translational modification: Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion. Involvement in disease: Osteogenesis imperfecta 13 (OI13) [MIM:614856]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both upper and lower limbs.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Ref.14. Sequence similarities: Belongs to the peptidase M12A family.Contains 5 CUB domains.Contains 2 EGF-like domains.

96 Strip Wells

600 USD