catalog number :
MBS020036
products type :
ELISA Kit
products full name :
Human Calnexin ELISA Kit
products short name :
Calnexin
other names :
calnexin; Calnexin; calnexin; major histocompatibility complex class I antigen-binding protein p88; calnexin; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
other gene names :
CANX; CANX; CNX; P90; IP90
uniprot entry name :
CALX_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Sandwich
ncbi acc num :
NP_001019820.1
ncbi gb acc num :
NM_001024649.1
ncbi mol weight :
67,568 Da
ncbi pathways :
Adaptive Immune System Pathway (366160); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Asparagine N-linked Glycosylation Pathway (161013); Assembly Of Viral Components At The Budding Site Pathway (106084); Calnexin/calreticulin Cycle Pathway (187218); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Disease Pathway (530764); HTLV-I Infection Pathway (373901)
ncbi summary :
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
uniprot summary :
Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum .Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Calcium-binding; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 5q35. Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; rough endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum; dendritic spine; cell soma; membrane; axon; melanosome; ribosome. Molecular Function: ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; carbohydrate binding; glycoprotein binding. Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging