ELISA/assay

Human Podoplanin ELISA Kit

MBS019924

48-Strip-Wells

435 USD

ELISA Kit

Human Podoplanin ELISA Kit

Podoplanin

podoplanin isoform d; Podoplanin; podoplanin; T1-alpha; hT1alpha-1; hT1alpha-2; PA2.26 antigen; glycoprotein 36; glycoprotein, 36-KD; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); podoplanin; Aggrus; Glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha

PDPN

PDPN; PDPN; T1A; GP36; GP40; Gp38; OTS8; T1A-2; AGGRUS; HT1A-1; PA2.26; GP36; Gp36; T1A

PDPN_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma and Tissue Homogenate. Detection Range: 31.2pg/ml-1000pg/ml. Sensitivity: 5.0pg/ml. Assay Type: Sandwich

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PDPN (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

54792062

NP_001006626.1

NM_001006625.1

Q86YL7

16,698 Da

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PDPN: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p36.21. Cellular Component: ruffle; filopodium membrane; microvillus membrane; integral to plasma membrane; lamellipodium; apical plasma membrane; plasma membrane; external side of plasma membrane; filopodium. Molecular Function: folic acid transporter activity; water transporter activity; water channel activity; amino acid transmembrane transporter activity. Biological Process: nervous system development; water transport; cell morphogenesis; positive regulation of cell motility; signal transduction; prostaglandin metabolic process; folic acid transport; regulation of cell shape; cell proliferation; cell-cell adhesion; response to hyperoxia; amino acid transport; lymphangiogenesis; inflammatory response; tube morphogenesis; alveolus development; lung development; positive regulation of cell migration

48-Strip-Wells

435 USD

96-Strip-Wells

600