Mouse Glucokinase ELISA Kit | MyBioSource MBS019216 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Glucokinase ELISA Kit

catalog :

MBS019216

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS019216

products type :

ELISA Kit

products full name :

Mouse Glucokinase ELISA Kit

products short name :

[Glucokinase]

other names :

[glucokinase; Glucokinase; glucokinase; HK IV; hexokinase 4; hexokinase-4; hexokinase-D; hexokinase type IV; glucokinase; Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D]

products gene name :

[GCK]

other gene names :

[Gck; Gck; Gk; GLK; HK4; HKIV; HXKP; MODY2; Gls006; Gk; HK IV; HK4]

uniprot entry name :

HXK4_MOUSE

reactivity :

Mouse

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 6.25 U/L - 200 U/L. Sensitivity: 1.0 U/L.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GCK (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

31982798

ncbi acc num :

NP_034422.2

ncbi gb acc num :

NM_010292.4

uniprot acc num :

P52792

ncbi mol weight :

52,089 Da

ncbi pathways :

Amino Sugar And Nucleotide Sugar Metabolism Pathway (83178); Amino Sugar And Nucleotide Sugar Metabolism Pathway (350); Butirosin And Neomycin Biosynthesis Pathway (145810); Butirosin And Neomycin Biosynthesis Pathway (145786); Carbon Metabolism Pathway (815838); Carbon Metabolism Pathway (817567); Developmental Biology Pathway (820229); GDP-glucose Biosynthesis Pathway (142845); Galactose Metabolism Pathway (83131); Galactose Metabolism Pathway (292)

uniprot summary :

GK: a glycolytic enzyme that catalyzes glucose metabolism in the liver and pancreatic beta cells. Acts as a glucose sensor in beta cells. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. Glucokinase traps glucose inside the cell by catalyzing its phosphorylation to produce glucose-6-phosphate. Has a lower affinity for glucose than the three other isozymes of hexokinase, allowing other organs such as the brain and muscles to have first call on glucose when its supply is limited. Unlike other hexokinases, glucokinase is not inhibited by glucose-6-phosphate. Glucokinase is found in the outer membrane compartment of mitochondria. May bind VDAC, suppressing mitochondrial function. Glucokinase transcription is induced by insulin, perhaps via the activation of Stat 5B. Mutant glucokinase causes a rare form of diabetes and may also play a role in type 2 diabetes. Three splice variant isoforms of human glucokinase have been described. Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Kinase, other; Carbohydrate Metabolism - galactose; Mitochondrial; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.1.2; Carbohydrate Metabolism - starch and sucrose. Cellular Component: nucleoplasm; mitochondrion; cell; cytoplasm; actin filament; cell cortex; cytosol; basal cortex; nucleus; secretory granule. Molecular Function: transferase activity; hexokinase activity; protein binding; magnesium ion binding; nucleotide binding; kinase activity; ADP binding; phosphotransferase activity, alcohol group as acceptor; glucokinase activity; protein phosphatase binding; ATP binding; glucose binding. Biological Process: positive regulation of glycogen biosynthetic process; glucose 6-phosphate metabolic process; lipid homeostasis; glucose homeostasis; NADP metabolic process; cellular response to glucose starvation; elevation of cytosolic calcium ion concentration; detection of glucose; negative regulation of gluconeogenesis; second-messenger-mediated signaling; glycogen biosynthetic process; glycolysis; regulation of potassium ion transport; glucose metabolic process; positive regulation of insulin secretion; fructose 2,6-bisphosphate metabolic process; cellular response to insulin stimulus; carbohydrate metabolic process; carbohydrate phosphorylation; positive regulation of glycolysis; negative regulation of epinephrine secretion; cell glucose homeostasis; regulation of insulin secretion; phosphorylation; positive regulation of phosphorylation

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095