Human Glutamine Synthetase ELISA Kit | MyBioSource MBS019167 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Glutamine Synthetase ELISA Kit

catalog :

MBS019167

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS019167

products type :

ELISA Kit

products full name :

Human Glutamine Synthetase ELISA Kit

products short name :

Glutamine Synthetase

other names :

glutamine synthetase; Glutamine synthetase; glutamine synthetase; glutamine synthase; glutamate decarboxylase; glutamate--ammonia ligase; proliferation-inducing protein 43; cell proliferation-inducing protein 59; glutamate-ammonia ligase; Glutamate decarboxylase (EC:4.1.1.15); Glutamate--ammonia ligase

products gene name :

other gene names :

GLUL; GLUL; GS; GLNS; PIG43; PIG59; GLNS; GS

uniprot entry name :

GLNA_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 3.12 U/L - 100 U/L. Sensitivity: 1.0 U/L.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GS (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

ncbi gi num :

74271837

ncbi acc num :

NP_001028216.1

ncbi gb acc num :

NM_001033044.2

uniprot acc num :

P15104

ncbi mol weight :

42,064 Da

ncbi pathways :

Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway (106533); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); GABAergic Synapse Pathway (377263); GABAergic Synapse Pathway (377129)

ncbi summary :

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

uniprot summary :

GLUL: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner. Essential for proliferation of fetal skin fibroblasts. Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD). CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. Belongs to the glutamine synthetase family. Protein type: Ligase; Energy Metabolism - nitrogen; Amino Acid Metabolism - arginine and proline; EC 4.1.1.15; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 6.3.1.2. Chromosomal Location of Human Ortholog: 1q31. Cellular Component: protein complex; rough endoplasmic reticulum; mitochondrion; cytoplasm; perikaryon; nerve terminal; cytosol; nucleus. Molecular Function: glutamate-ammonia ligase activity; identical protein binding; dynein light chain binding; glutamate binding; glutamate decarboxylase activity; manganese ion binding; magnesium ion binding; ATP binding. Biological Process: glutamate catabolic process; cell proliferation; synaptic transmission; glutamine biosynthetic process; response to glucose stimulus; neurotransmitter uptake; positive regulation of insulin secretion; amino acid biosynthetic process; cellular response to starvation; positive regulation of synaptic transmission, glutamatergic; positive regulation of epithelial cell proliferation; protein homooligomerization. Disease: Glutamine Deficiency, Congenital

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage