catalog number :
MBS017966
products type :
ELISA Kit
products full name :
Human Aquaporin 3, Gill Blood Group ELISA Kit
products short name :
[Aquaporin 3, Gill Blood Group]
other names :
[aquaporin-3; Aquaporin-3; aquaporin-3; aquaglyceroporin-3; aquaporin 3 (GIL blood group); aquaporin 3 (Gill blood group); Aquaglyceroporin-3]
products gene name :
[AQP-3]
other gene names :
[AQP3; AQP3; GIL; AQP-3; AQP-3]
uniprot entry name :
AQP3_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Quantitative Sandwich. Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of AQP-3 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_004916.1
ncbi gb acc num :
NM_004925.4
ncbi mol weight :
31,544 Da
ncbi pathways :
Aquaporin-mediated Transport Pathway (187187); Passive Transport By Aquaporins Pathway (187188); Regulation Of Water Balance By Renal Aquaporins Pathway (187189); Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway (137918); Transmembrane Transport Of Small Molecules Pathway (106572); Vasopressin-regulated Water Reabsorption Pathway (143700); Vasopressin-regulated Water Reabsorption Pathway (143631)
ncbi summary :
This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]
uniprot summary :
AQP3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family; Channel, misc. Chromosomal Location of Human Ortholog: 9p13. Cellular Component: integral to plasma membrane; basolateral plasma membrane; cytoplasm; integral to membrane; plasma membrane; intercellular junction. Molecular Function: transporter activity; urea transmembrane transporter activity; water channel activity; glycerol channel activity. Biological Process: positive regulation of immune system process; glycerol transport; response to retinoic acid; cellular water homeostasis; water transport; excretion; odontogenesis; response to vitamin D; transport; renal water homeostasis; response to calcium ion; regulation of keratinocyte differentiation; transmembrane transport. Disease: Gil Blood Group
size4 :
10x96-Strip-Wells