ELISA/assay

Mouse Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 ELISA Kit

MBS017560

96 Strip Wells

600 USD

ELISA Kit

Mouse Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 ELISA Kit

Cytochrome P450, Family 19, Subfamily A, Polypeptide 1

cytochrome P450 19A1; Cytochrome P450 19A1; cytochrome P450 19A1; aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens); cytochrome P450, family 19, subfamily A, polypeptide 1; Aromatase; CYPXIX; Cytochrome P-450AROM; Estrogen synthase

CYP19A1

CYP19A1; CYP19A1; ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM; ARO1; CYAR; CYP19

CP19A_HUMAN

Mouse

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

13904860

NP_112503.1

NM_031226.2

P11511

57,883 Da

Biological Oxidations Pathway 105698!!C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway 413383!!C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway 468268!!Cytochrome P450 - Arranged By Substrate Type Pathway 105700!!Endogenous Sterols Pathway 105701!!Estrogen Biosynthesis Pathway 106155!!FSH Signaling Pathway 672455!!Integrated Breast Cancer Pathway 219801!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]

Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Catalytic activity: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. Cofactor: Heme group. Subcellular location: Membrane; Peripheral membrane protein. Tissue specificity: Brain, placenta and gonads. Ref.10 Ref.12 Ref.13 Ref.15. Involvement in disease: Aromatase excess syndrome (AEXS) [MIM:139300]: An autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females.Note: The disease is caused by mutations affecting the gene represented in this entry.Aromatase deficiency (AROD) [MIM:613546]: A rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17 Ref.18 Ref.19. Sequence similarities: Belongs to the cytochrome P450 family.

96 Strip Wells

600 USD