ELISA/assay

Human Signal Transducer and Activator of Transcription 2 ELISA Kit

MBS016630

96 Strip Wells

600 USD

ELISA Kit

Human Signal Transducer and Activator of Transcription 2 ELISA Kit

Signal Transducer and Activator of Transcription 2

Stat2; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2; interferon alpha induced transcriptional activator; signal transducer and activator of transcription 2, 113kDa; p113

STAT2

STAT2; STAT2; P113; ISGF-3; STAT113

STAT2_HUMAN

Human

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

1293920

AAA98760.1

P52630

97,916 Da

Adipogenesis Pathway 198832!!CXCR4-mediated Signaling Events Pathway 137910!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Cytokine Signaling In Immune System Pathway 366171!!EGFR1 Signaling Pathway 198782!!Hepatitis B Pathway 694606!!Hepatitis C Pathway 173973!!Hepatitis C Pathway 173907!!Herpes Simplex Infection Pathway 377873

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Function: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Ref.10. Subunit structure: Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein . By similarity. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with dengue virus NS5; this interaction inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation. Interacts with human cytomegalovirus/HHV-5 protein UL123; this interaction promotes viral growth. Ref.10 Ref.11 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18. Subcellular location: Cytoplasm. Nucleus. Note: Translocated into the nucleus upon activation by IFN-alpha/beta. Ref.13 Ref.20. Post-translational modification: Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response. Ref.7 Ref.8 Ref.11 Ref.20. Sequence similarities: Belongs to the transcription factor STAT family.Contains 1 SH2 domain. Sequence caution: The sequence AAB36226.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAB36227.1 differs from that shown. Reason: Erroneous gene model prediction.

96 Strip Wells

600 USD