ELISA/assay

Mouse Glycoprotein V, Platelet ELISA Kit

MBS015725

48-Strip-Wells

435 USD

ELISA Kit

Mouse Glycoprotein V, Platelet ELISA Kit

Glycoprotein V, Platelet

glycoprotein V (platelet); Platelet glycoprotein V; platelet glycoprotein V; glycoprotein 5; glycoprotein V (platelet); Glycoprotein 5

GP5

GP5; GP5; GPV; CD42d; GPV

GPV_HUMAN

Mouse

No significant cross-reactivity or interference between Mouse GP5 and analogues was observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Assay Type: Sandwich. Detection Range: 6.25 ng/ml - 200 ng/ml. Sensitivity: 1.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate GP5 concentrations in Mouse serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications!

269819656

ACZ44929.1

P40197

60,959 Da

ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); GP1b-IX-V Activation Signalling Pathway (187205); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Hemostasis Pathway (106028); Intrinsic Pathway (106059); Platelet Adhesion To Exposed Collagen Pathway (106030); Platelet Aggregation (Plug Formation) Pathway (106053)

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]

GPV: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. Protein type: Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q29. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: collagen binding. Biological Process: platelet activation; cell-matrix adhesion; blood coagulation; cell adhesion; blood coagulation, intrinsic pathway

48-Strip-Wells

435 USD

96-Strip-Wells

600