catalog number :
MBS013923
products type :
ELISA Kit
products full name :
Hamster Thioredoxin ELISA Kit
products short name :
[Thioredoxin]
other names :
[thioredoxin; Thioredoxin; thioredoxin; trx; ATL-derived factor; thioredoxin 1; ATL-derived factor]
products gene name :
[TRX]
other gene names :
[Txn1; Txn; ADF; Txn; Trx1; AW550880; Txn1; Trx; ADF]
uniprot entry name :
THIO_MOUSE
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Hamster body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TRX (hereafter termed "analyte") in undiluted original Hamster body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_035790.1
ncbi gb acc num :
NM_011660.3
ncbi mol weight :
11,675 Da
ncbi pathways :
Immune System Pathway (819567); Inflammasomes Pathway (819646); Innate Immune System Pathway (819596); Metabolism Pathway (819200); Metabolism Of Nucleotides Pathway (819361); Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways (819644); Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway (819370); The NLRP3 Inflammasome Pathway (819647)
uniprot summary :
TXN: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. Up-regulated by ionizing radiation. Belongs to the thioredoxin family. Protein type: Nuclear receptor co-regulator. Cellular Component: mitochondrion; cell soma; axon; dendrite; cytoplasm; extracellular region; nucleus; cytosol. Molecular Function: protein binding; enzyme binding; protein disulfide oxidoreductase activity; peptide disulfide oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor. Biological Process: response to radiation; sulfate assimilation; negative regulation of protein export from nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein folding; transport; cell redox homeostasis; regulation of protein import into nucleus, translocation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation; glycerol ether metabolic process; positive regulation of DNA binding
size4 :
10x96-Strip-Wells