Mouse Collagen Type IX alpha1 ELISA Kit | MyBioSource MBS013618 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Collagen Type IX alpha1 ELISA Kit

catalog :

MBS013618

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS013618

products type :

ELISA Kit

products full name :

Mouse Collagen Type IX alpha1 ELISA Kit

products short name :

[Collagen Type IX alpha1]

other names :

[collagen alpha-1(IX) chain isoform 1; Collagen alpha-1(IX) chain; collagen alpha-1(IX) chain; collagen alpha-1(IX) chain; alpha-1(IX) collagen chain; collagen IX, alpha-1 polypeptide; cartilage-specific short collagen; collagen, type IX, alpha 1]

products gene name :

[COL9A1]

other gene names :

[COL9A1; COL9A1; MED; EDM6; STL4; DJ149L1.1.2]

uniprot entry name :

CO9A1_HUMAN

reactivity :

Mouse

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Sandwich

ncbi gi num :

73486666

ncbi acc num :

NP_001842.3

ncbi gb acc num :

NM_001851.4

uniprot acc num :

P20849

ncbi mol weight :

91,869 Da

ncbi pathways :

Axon Guidance Pathway (105688); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Formation Pathway (645288); Degradation Of Collagen Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Developmental Biology Pathway (477129); ECM Proteoglycans Pathway (833812); Extracellular Matrix Organization Pathway (576262); Gastric Cancer Network 2 Pathway (760637); NCAM Signaling For Neurite Out-growth Pathway (105689)

ncbi summary :

This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects. Two transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

COL9A1: Structural component of hyaline cartilage and vitreous of the eye. Defects in COL9A1 are the cause of multiple epiphyseal dysplasia type 6 (EDM6). A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. Defects in COL9A1 are the cause of Stickler syndrome type 4 (STL4). An autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or chorioretinal degeneration, retinal detachment, and chronic uveitis. Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more severe over time. Syndrome expressivity is variable. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6q13. Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region. Molecular Function: metal ion binding; extracellular matrix structural constituent conferring tensile strength. Biological Process: axon guidance; collagen catabolic process; extracellular matrix disassembly; organ morphogenesis; extracellular matrix organization and biogenesis; tissue homeostasis. Disease: Stickler Syndrome, Type Iv; Epiphyseal Dysplasia, Multiple, 6

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095