catalog number :
MBS013242
products type :
ELISA Kit
products full name :
Human Thymic Stromal Lymphopoietin ELISA Kit
products short name :
Thymic Stromal Lymphopoietin
other names :
thymic stromal lymphopoietin isoform 2; Thymic stromal lymphopoietin; thymic stromal lymphopoietin; thymic stromal lymphopoietin
products gene name :
TSLP
other gene names :
TSLP; TSLP
uniprot entry name :
TSLP_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
ELISA Type: Sandwich
ncbi acc num :
NP_612561.2
ncbi gb acc num :
NM_138551.4
ncbi mol weight :
18,141 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Jak-STAT Signaling Pathway 83077!!Jak-STAT Signaling Pathway 488!!TSLP Signaling Pathway 672451
ncbi summary :
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
uniprot summary :
Function: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells. Ref.1 Ref.2 Ref.4. Subunit structure: Interacts with a receptor composed of CRLF2 and IL7R. Subcellular location: Secreted Ref.1. Tissue specificity: Expressed in a number of tissues including heart, liver and prostate. Ref.2. Induction: Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines. Ref.4