Rat P Selectin ELISA Kit | MyBioSource MBS012813 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat P Selectin ELISA Kit

catalog :

MBS012813

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS012813

products type :

ELISA Kit

products full name :

Rat P Selectin ELISA Kit

products short name :

P Selectin

other names :

P-selectin; P-selectin; P-selectin; GMP-140; granule membrane protein 140; granulocyte membrane protein; CD62 antigen-like family member P; platelet alpha-granule membrane protein; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein; selectin P (granule membrane protein 140kDa, antigen CD62); CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein

products gene name :

P-SELECTIN

other gene names :

SELP; SELP; CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM; GMRP; GRMP; GMP-140; LECAM3; PADGEM

uniprot entry name :

LYAM3_HUMAN

reactivity :

Rat

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 6.25 ng/ml - 200 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PS (hereafter termed this analyte) in undiluted original Rat serum, plasma and tissue homogenate samples.

ncbi gi num :

157419154

ncbi acc num :

NP_002996.2

ncbi gb acc num :

NM_003005.3

uniprot acc num :

P16109

ncbi mol weight :

90,834 Da

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Hemostasis Pathway (106028); IL-3 Signaling Pathway (198881); IL4-mediated Signaling Events Pathway (137933); Malaria Pathway (152665); Malaria Pathway (152657); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050)

ncbi summary :

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

uniprot summary :

SELP: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the selectin/LECAM family. Protein type: Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q22-q25. Cellular Component: nucleoplasm; extracellular space; platelet alpha granule membrane; integral to plasma membrane; cytoplasm; plasma membrane; platelet dense granule membrane; external side of plasma membrane. Molecular Function: heparin binding; protein binding; lipopolysaccharide binding; glycoprotein binding; glycosphingolipid binding; calcium-dependent protein binding; sialic acid binding; fucose binding. Biological Process: platelet activation; positive regulation of leukocyte migration; response to lipopolysaccharide; defense response to Gram-negative bacterium; heterophilic cell adhesion; positive regulation of phosphoinositide 3-kinase cascade; leukocyte adhesion; platelet degranulation; regulation of integrin activation; blood coagulation; leukocyte tethering or rolling; inflammatory response; cell adhesion; leukocyte migration. Disease: Ige Responsiveness, Atopic

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage