catalog number :
MBS012301
products type :
ELISA Kit
products full name :
Rat N-Terminal Pro-Brain Natriuretic Peptide ELISA Kit
products short name :
N-Terminal Pro-Brain Natriuretic Peptide
other names :
natriuretic peptides B preproprotein; Natriuretic peptides B; natriuretic peptides B; natriuretic protein; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B; natriuretic peptide B; Gamma-brain natriuretic peptide
products gene name :
NT-PROBNP
other gene names :
NPPB; NPPB; BNP; BNP(1-32); BNP-32
uniprot entry name :
ANFB_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
ELISA Type: Sandwich
ncbi acc num :
NP_002512.1
ncbi gb acc num :
NM_002521.2
ncbi mol weight :
14,726 Da
ncbi pathways :
MicroRNAs In Cardiomyocyte Hypertrophy Pathway 198784!!CGMP-PKG Signaling Pathway 983748!!CGMP-PKG Signaling Pathway 985584
ncbi summary :
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Ref.11. Subcellular location: Secreted. Tissue specificity: Brain and also in atria, but at much lower levels than ANP. Pharmaceutical use: Available under the name Nesiritide (Scios). Used for the treatment of heart failure. Sequence similarities: Belongs to the natriuretic peptide family. Sequence caution: The sequence BAA90441.1 differs from that shown. Reason: Frameshift at position 44.