ELISA/assay

Human Regenerating Islet Derived Protein 1 Alpha ELISA Kit

MBS012045

96 Strip Wells

600 USD

ELISA Kit

Human Regenerating Islet Derived Protein 1 Alpha ELISA Kit

Regenerating Islet Derived Protein 1 Alpha

regenerating islet-derived protein 3-alpha; Regenerating islet-derived protein 3-alpha; regenerating islet-derived protein 3-alpha; REG-3-alpha; reg III-alpha; PAP homologous protein; human proislet peptide; pancreatitis-associated protein 1; proliferation-inducing protein 34; proliferation-inducing protein 42; hepatocarcinoma-intestine-pancreas; pancreatic beta cell growth factor; hepatointestinal pancreatic protein; regenerating islet-derived protein III-alpha; regenerating islet-derived 3 alpha; Hepatointestinal pancreatic protein; HIP/PAP; Human proislet peptide; Pancreatitis-associated protein 1; Regenerating islet-derived protein III-alpha

REG1alpha

REG3A; REG3A; HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III; HIP; PAP; PAP1; REG-3-alpha; HIP/PAP

REG3A_HUMAN

Human

175

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

4505605

NP_002571.1

NM_002580.2

Q06141

19,395 Da

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Dec 2010]

Function: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. Ref.8. Subunit structure: Interacts with EXTL3. Ref.9. Subcellular location: Secreted. Note: Found in the apical region of pancreatic acinar cells. Tissue specificity: Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. Ref.2 Ref.9. Induction: Appears in pancreatic juice after induction of pancreatic inflammation. Domain: The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity. Post-translational modification: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. Sequence similarities: Contains 1 C-type lectin domain.

96 Strip Wells

600 USD