Mouse Doublecortin ELISA Kit | MyBioSource MBS011832 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Doublecortin ELISA Kit

catalog :

MBS011832

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS011832

products type :

ELISA Kit

products full name :

Mouse Doublecortin ELISA Kit

products short name :

[Doublecortin]

other names :

[doublecortin; Neuronal migration protein doublecortin; neuronal migration protein doublecortin; lis-X; doublin; doublecortex; lissencephalin-X; doublecortin; Doublin; Lissencephalin-X]

products gene name :

[DCX]

other gene names :

[DCX; DCX; DC; DBCN; LISX; SCLH; XLIS; DBCN; LISX; Lis-X]

uniprot entry name :

DCX_HUMAN

reactivity :

Mouse

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Sandwich (Quantitative). Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DCX (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

3114810

ncbi acc num :

CAA06617.1

uniprot acc num :

O43602

ncbi mol weight :

49,318 Da

ncbi pathways :

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); L1CAM Interactions Pathway (161003); Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway (137984); Neurofascin Interactions Pathway (161008)

ncbi summary :

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

uniprot summary :

Doublecortin: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration. Interacts with tubulin. Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: Xq22.3-q23. Cellular Component: microtubule; microtubule associated complex; neuron projection; cytoskeleton; cytosol. Molecular Function: protein binding; microtubule binding; protein kinase binding. Biological Process: axon guidance; nervous system development; central nervous system development; axon extension; dendrite morphogenesis; neuron migration; central nervous system projection neuron axonogenesis; brain development. Disease: Lissencephaly, X-linked, 1

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095