ELISA/assay

Bovine Transforming Growth Factor Alpha ELISA Kit

MBS010106

48-Strip-Wells

435 USD

ELISA Kit

Bovine Transforming Growth Factor Alpha ELISA Kit

Transforming Growth Factor Alpha

transforming growth factor-alpha; Protransforming growth factor alpha; protransforming growth factor alpha; TGF-alpha; transforming growth factor, alpha; EGF-like TGF; ETGF; TGF type 1

TGFA

TGFA; TGFA; TFGA; TGF-alpha; ETGF

TGFA_HUMAN

Bovine

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 3.12 pg/ml - 100 pg/ml. Sensitivity: 1.0 pg/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TGFA (hereafter termed this analyte) in undiluted original Bovine serum, plasma and tissue homogenate samples.

6469923

AAF13491.1

P01135

17,006 Da

Direct P53 Effectors Pathway (137939); ErbB Receptor Signaling Network Pathway (138016); ErbB Signaling Pathway (198844); ErbB Signaling Pathway (83049); ErbB Signaling Pathway (458); FOXM1 Transcription Factor Network Pathway (137935); Glioma Pathway (83110); Glioma Pathway (522); Non-small Cell Lung Cancer Pathway (83119); Non-small Cell Lung Cancer Pathway (531)

This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

TGFalpha: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Cell cycle regulation; Motility/polarity/chemotaxis; Membrane protein, integral; Ligand, receptor tyrosine kinase. Chromosomal Location of Human Ortholog: 2p13. Cellular Component: extracellular space; cell surface; basolateral plasma membrane; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; cytoplasmic vesicle; nucleus. Molecular Function: protein binding; growth factor activity; glycoprotein binding; epidermal growth factor receptor binding. Biological Process: response to drug; epidermal growth factor receptor signaling pathway; cell proliferation; wound healing; positive regulation of mitosis; positive regulation of epidermal growth factor receptor activity; activation of MAPK activity; angiogenesis; positive regulation of epithelial cell proliferation; negative regulation of apoptosis

48-Strip-Wells

435 USD

96-Strip-Wells

600