Mouse Endothelin Receptor B ELISA Kit | MyBioSource MBS009737 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Endothelin Receptor B ELISA Kit

catalog :

MBS009737

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS009737

products type :

ELISA Kit

products full name :

Mouse Endothelin Receptor B ELISA Kit

products short name :

[Endothelin Receptor B]

other names :

[endothelin B receptor; Endothelin B receptor; endothelin B receptor; piebald; endothelin receptor non-selective type; endothelin receptor type B; Endothelin receptor non-selective type]

products gene name :

[ETR-B]

other gene names :

[Ednrb; Ednrb; ETb; ET-B; ET-BR; ETR-b; Sox10m1; ET-B; ET-BR]

uniprot entry name :

EDNRB_MOUSE

reactivity :

Mouse

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ETR-B (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

443609487

ncbi acc num :

NP_001263225.1

ncbi gb acc num :

NM_001276296.1

uniprot acc num :

P48302

ncbi mol weight :

49,561 Da

ncbi pathways :

Calcium Signaling Pathway (83247); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (819840); G Alpha (q) Signalling Events Pathway (819873); GPCR Downstream Signaling Pathway (819869); GPCR Ligand Binding Pathway (819839); GPCRs, Class A Rhodopsin-like Pathway (198308); Gastrin-CREB Signalling Pathway Via PKC And MAPK (819888); Melanogenesis Pathway (83289); Melanogenesis Pathway (504)

ncbi summary :

This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

uniprot summary :

ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described. Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral. Cellular Component: nuclear membrane; membrane; integral to membrane; plasma membrane; cytosol; lipid raft. Molecular Function: endothelin receptor activity; G-protein coupled receptor activity; protein binding; signal transducer activity; peptide hormone binding; type 1 angiotensin receptor binding. Biological Process: epithelial fluid transport; cGMP-mediated signaling; pigmentation during development; regulation of fever; response to lipopolysaccharide; negative regulation of cellular protein metabolic process; response to pain; negative regulation of transcription from RNA polymerase II promoter; vein smooth muscle contraction; sensory perception of pain; signal transduction; enteric nervous system development; vasodilation; regulation of epithelial cell proliferation; elevation of cytosolic calcium ion concentration; regulation of blood pressure; positive regulation of cell proliferation; melanocyte differentiation; regulation of pH; neural crest cell migration; posterior midgut development; vasoconstriction; macrophage chemotaxis; peripheral nervous system development; G-protein coupled receptor protein signaling pathway; negative regulation of neuron maturation; pigmentation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095