ELISA/assay

Fish Hemoglobin-Advanced Glycosylation End Products ELISA Kit

MBS009525

48-Strip-Wells

470 USD

ELISA Kit

Fish Hemoglobin-Advanced Glycosylation End Products ELISA Kit

[Hemoglobin-Advanced Glycosylation End Products]

[Hemoglobin subunit gamma-2; Hemoglobin subunit gamma-2; hemoglobin subunit gamma-2; hb F Ggamma; methemoglobin; gamma-2-globin; abnormal hemoglobin; G-gamma globin Paulinia; hemoglobin gamma-2 chain; hemoglobin gamma-G chain; hemoglobin, gamma G; Gamma-2-globin; Hb F Ggamma; Hemoglobin gamma-2 chain; Hemoglobin gamma-G chain]

[HB-AGE]

[HBG2; HBG2; TNCY; HBG-T1]

HBG2_HUMAN

Fish

147

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 31.2 ng/ml - 1000 ng/ml. Sensitivity: 5.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of HB-AGE (hereafter termed "analyte") in undiluted original Fish body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

56749861

P69892.2

P69892

16,126 Da

Factors Involved In Megakaryocyte Development And Platelet Production Pathway (187196); Hemostasis Pathway (106028)

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

HBG2: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. Defects in HBG2 are the cause of cyanosis transient neonatal (TNCY). TNCY is a disorder characterized by cyanosis in the fetus and neonate, due to a defect in the fetal hemoglobin chain which has reduced affinity for oxygen. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain is produced and replaces the fetal gamma- globin chain. Belongs to the globin family. Protein type: Carrier. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: hemoglobin complex; cytosol. Molecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activity. Biological Process: oxygen transport; blood coagulation. Disease: Cyanosis, Transient Neonatal; Fetal Hemoglobin Quantitative Trait Locus 1

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095