ELISA/assay

Rat Cx3C-Chemokine/Fractalkine ELISA Kit

MBS009314

96 Strip Wells

600 USD

ELISA Kit

Rat Cx3C-Chemokine/Fractalkine ELISA Kit

Cx3C-Chemokine/Fractalkine

CX3C chemokine receptor 1 isoform b; CX3C chemokine receptor 1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28

FKN

CX3CR1; CX3CR1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CMKBRL1; GPR13; C-X3-C CKR-1; CX3CR1; CMK-BRL1

CX3C1_HUMAN

Rat

355

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

4503171

NP_001328.1

NM_001337.3

P49238

40,396 Da

Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!GPCR Ligand Binding Pathway 161020!!GPCRs, Class A Rhodopsin-like Pathway 198886!!Peptide GPCRs Pathway 198897!!Peptide Ligand-binding Receptors Pathway 106358

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Function: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Subunit structure: Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160. Ref.10. Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Expressed in lymphoid and neural tissues. Polymorphism: Variations in CX3CR1 are associated with rapid progression to AIDS [. MIM:609423]. Increased susceptibility to HIV infection and rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype. Involvement in disease: Macular degeneration, age-related, 12 (ARMD12) [MIM:613784]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.16 Ref.17. Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

96 Strip Wells

600 USD