ELISA/assay

Rat Phosphorylated Alpha Synuclein ELISA Kit

MBS008653

48-Strip-Wells

435 USD

ELISA Kit

Rat Phosphorylated Alpha Synuclein ELISA Kit

Phosphorylated Alpha Synuclein

alpha-synuclein; Alpha-synuclein; alpha-synuclein; alpha SYN; non-A4 component of amyloid; non-A beta component of AD amyloid; synuclein, alpha; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor

PSNCA

Snca; Snca; NACP; alphaSYN; Syn; NACP

SYUA_MOUSE

Rat

No significant cross-reactivity or interference between Rat PSNCA and analogues was observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate PSNCA concentrations in Rat serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications!

109638747

NP_001035916.1

NM_001042451.1

O55042

14,485 Da

Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Amyloids Pathway (819491); Disease Pathway (819462); EGFR1 Signaling Pathway (198278); Parkinson's Disease Pathway (83295)

SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson s disease. A major component of amyloid plaques in the brains of patients with Alzheimer s disease. Two alternatively spliced isoforms transcripts have been identified. Protein type: Adaptor/scaffold. Cellular Component: Golgi apparatus; nuclear outer membrane; cytoplasmic vesicle membrane; intracellular membrane-bound organelle; mitochondrion; rough endoplasmic reticulum; cell; fibril; terminal button; cell cortex; inclusion body; cytosol; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; cytoskeleton; growth cone; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; ribosome; synapse; nerve terminal; nucleus. Molecular Function: protein domain specific binding; identical protein binding; zinc ion binding; histone binding; kinesin binding; microtubule binding; metal ion binding; ferrous iron binding; caspase inhibitor activity; beta-tubulin binding; magnesium ion binding; phosphoprotein binding; protein N-terminus binding; oxidoreductase activity; Hsp70 protein binding; calcium ion binding; arachidonic acid binding; dynein binding; protein binding; copper ion binding; enzyme binding; phospholipase binding; phospholipid binding; tau protein binding; alpha-tubulin binding. Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; regulation of neurotransmitter secretion; positive regulation of endocytosis; response to lipopolysaccharide; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; dopamine metabolic process; response to magnesium ion; regulation of neuron apoptosis; synapse organization and biogenesis; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of neuronal synaptic plasticity; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; synaptic transmission, dopaminergic; negative regulation of norepinephrine uptake; mitochondrial membrane organization and biogenesis; microglial cell activation; negative regulation of monooxygenase activity; negative regulation of caspase activity; fatty acid metabolic process; regulation of dopamine secretion; positive regulation of synaptic transmission; negative regulation of histone acetylation; negative regulation of dopamine uptake; synaptic transmission; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; receptor internalization; phospholipid metabolic process; response to iron(II) ion; positive regulation of receptor recycling; caspase activation; neutral lipid metabolic process; protein destabilization; regulation of macrophage activation; negative regulation of microtubule polymerization; regulation of glutamate secretion; synaptic vesicle transport; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential

48-Strip-Wells

435 USD

96-Strip-Wells

600